Understanding the Role of the Gut Microbiome in Diabetes and Therapeutics Targeting Leaky Gut: A Systematic Review

The gut microbiota has been studied and continues to be a developing area in the pathognomic development of metabolic diseases like diabetes. Treatment with diet changes, addition supplements prebiotics/probiotics, impact fecal microbial transplantation can correlated targeting changes dysbiosis. Understanding impacts various anti-hyperglycemic agents such as metformin implications post-bariatric surgery on diversity emerged. These areas study are crucial understanding aspects diabetes disease progression at level inflammatory mechanisms, which may give more insight into focusing role prebiotic/probiotic potential forms prospective management that target microbiota, harbors low-grade inflammation. Intestinal dysbiosis was consistently observed mechanism change diabetic individuals, contributing reduced insulin sensitivity poor glycemic control. This systematic review carried out using Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) 2020 checklist. We performed literature search PubMed, Google Scholar Science Direct databases accordance eligibility criteria ultimately selected 14 articles final analysis. Scale Assessment Narrative Review Articles (SANRA) PRISMA checklist were used assess quality cross-sectional studies, traditional reviews, respectively. collected papers from 2012 2022 this review. gathered databases, study, show there is strong connection between appears exist. objective identify any dietary therapeutic alter potentially modulate sensitivity. article will discuss pathophysiological effects biodiversity therapeutics aid reversing